User Talk: Bomb319

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http://www.who.int/medicines/publications/essentialmedicines/18th_EML.pdf ↗ <span style="color:#0000f1">'''Doc James'''</span> (talk · contribs ↗ · email ↗) (if I write on your page reply on mine) 02:34, 4 May 2014 (UTC)

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Your submission at Articles for creation ↗: Fern G.Z. Carr ↗ (May 24)

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'''<span style="color: #3BB9FF; font-style: italic; font-family: Lato, sans-serif'">Esquivalience</span> <sup><span style="color:#00B88A;">t</span></sup>''' 17:45, 24 May 2015 (UTC)</div>

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This text

"As an extreme example, a patient's immune system is entirely destroyed intentionally before a bone-marrow transplant is performed. This is done to ensure that the donor bone-marrow can enter the long bones and take hold - re-establishing an immune system without risking attack and inevitable destruction of these cells by a person's own bone-marrow."

is not exactly correct. A person immune system is entirely destroyed as this is a side effect of the severity of the chemotherapy used. As the immune system has been so negatively effected a bone marrow transplant is than needed to restore immune function as it is unable to recover on its own.

Please use references for the text you add. Best <span style="color:#0000f1">'''Doc James'''</span> (talk · contribs ↗ · email ↗) 22:13, 30 June 2015 (UTC)

Both are True

While chemotherapy does indeed have many nasty side effects which include immunosuppression, many bone marrow transplants are indeed preceded by an intentional destruction of natural immunity. This is known as myeloablation. I didn't cite it because it is stated on other relevant Wiki Pages - ie bone marrow transplant ↗ or myeloablation ↗. Here is the quote from that page:

Conditioning regimens
Myeloablative

The chemotherapy or irradiation given immediately prior to a transplant is called the conditioning regimen, the purpose of which is to help eradicate the patient's disease prior to the infusion of HSC and to suppress immune reactions. The bone marrow can be ablated (destroyed) with dose-levels that cause minimal injury to other tissues. In allogeneic transplants a combination of cyclophosphamide with total body irradiation is conventionally employed. This treatment also has an immunosuppressive effect that prevents rejection of the HSC by the recipient's immune system. The post-transplant prognosis often includes acute and chronic graft-versus-host disease that may be life-threatening. However, in certain leukemias this can coincide with protection against cancer relapse owing to the graft versus tumor effect.[19] Autologous transplants may also use similar conditioning regimens, but many other chemotherapy combinations can be used depending on the type of disease.

Also, here is another direct quote from that introduction:

"It is a medical procedure in the field of hematology, most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT."

Regardless, thank you for your input.
Bomb319 (talk) 22:38, 30 June 2015 (UTC)

Your submission at Articles for creation ↗: Fern G. Z. Carr ↗ (November 4)

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<span style="text-shadow:#A2E1FC 2px 2px 9px;">— <span style="font-family:Palatino Linotype; color:#000000;">kikichugirl</span> <sup><span style="color:#8A37F0;">oh hello!</span></sup></span> 05:53, 4 November 2015 (UTC)</div>

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Your submission at Articles for creation ↗: Fern G. Z. Carr ↗ (December 16)

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<b><span style="color:#536895;">Onel</span><span style="color:#FFB300;">5969</span></b> <sup><i style="color:blue">TT me</i></sup> 04:14, 16 December 2015 (UTC)</div>

Hi

I have nominated the recapture of El Chapo at ITN.--BabbaQ (talk) 20:37, 8 January 2016 (UTC)

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